Developing and constructing an advanced system for correlative label-free and fluorescence microscopy.

In the Department of Biology, Division of Animal Physiology and Neurobiology and the Department of Chemistry, Division of Biochemistry, Molecular, and Structural Biology, a FLOF-PhD position is available in the Laboratory of Prof. Wim Vandenberg.

Project

Optical imaging is a cornerstone of modern biological research, yet current methods face a fundamental problem: techniques that offer rich molecular-level information, such as fluorescence microscopy, require chemical labelling and struggle with long-term or non-invasive imaging, while label-free approaches like optical coherence tomography can image living tissue freely but yield signals that are difficult to interpret biologically. As a result, no existing method can simultaneously deliver non-invasive, and molecularly informative imaging of complex 3D samples such as organoids or tissue slices.
In this , the focus is set on developing a correlative imaging platform that combines fluorescence and ligh...