Job Responsibility
Design and develop toxicology-enabling formulations for in vivo preclinical studies (rodent and non-rodent), including: solutions, suspensions, emulsions, and lipid-based formulations. Select formulation approaches based on API physicochemical properties, exposure targets, and route of administration. Design and execute excipient compatibility studies, including lipid-API interactions. Assess chemical and physical stability under short-term and accelerated conditions appropriate for tox studies. Design and preform high throughput screening, solubility measurements and characterization. Characterize the generated samples using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermal Gravimetry Analysis (TGA), Liquid Nuclear Magnetic Resonance (NMR), Dynamic Vapor Sorption (DVS), Optical Microscope, Scanning Electron Microscope (SEM), Particle Size Analyzer and HPLC.
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